@article{78,
  keywords = {Freeze fracture, Oligo(malic acid), Small-angle X-ray scattering (SAXS), Sterically stabilized vesicle},
  author = {Attila Bóta and András Wacha and Zoltán Varga and Imola Szigyártó and Sándor Kristyán and András Lőrincz and Pál Szabó and Miklós Kálmán and Lívia Naszályi-Nagy and Judith Mihály},
  title = {Role of oligo(malic acid) on the formation of unilamellar vesicles},
  abstract = {Stable unilamellar dipalmitoylphosphatidylcholine vesicles were produced by using oligo(malic acid) and cholesterol. Detailed physico-chemical characterization prove that by using oligo(malic acid) the substitution of PEGylated lipids for sterically stabilization comes possible. The polymer molecules cover the outer surface of spherical-shaped vesicles, and an asymmetrical composition occurs in the two leaflets of the phospholipid bilayer. The oligo(malic-acid) and cholesterol are enriched in the outer side assuring the stabilization of vesicles. Cholesterol plays an important role in the self-assembly of components as it makes the entering of oligomers possible deep into the polar head-region of lipids. The presence of oligo(malic acid) molecules does not induce degradation by hydrolysis of lipid molecules but the vesicle system turns into a sensitive form giving a possibility for pH sensitive targeting. Preliminary investigation on the investigated oligo(malic acid)-stabilized vesicles do not show any toxic effect promising their applicability in the field of liposomal drug delivery.},
  year = {2018},
  journal = {Journal of Colloid and Interface Science},
  volume = {532},
  pages = {782–789},
  issn = {0021-9797},
  url = {http://www.sciencedirect.com/science/article/pii/S0021979718309342},
  doi = {10.1016/j.jcis.2018.08.020},
}