@article{450, author = {B. Kazi and L. Kiss and E. Forro and István Mándity and Ferenc Fülöp}, title = {Synthesis of conformationally constrained, orthogonally protected 3-azabicyclo[3.2.1]octane beta-amino esters}, abstract = {Novel azabicyclic beta-amino acid derivatives were readily prepared from diexo or diendo norbornene beta-amino acids. The 3-azabicyclo[3.2.1]octane skeleton was obtained by NaIO4-mediated cleavage of the dihydroxylated beta-amino ester intermediates, followed by reductive amination. Lipase-catalyzed enantioselective ring opening of racemic exo-norbornene beta-lactam allowed preparation of the corresponding azabicyclic exo beta-amino acid in enantiopure form.}, journal = {ARKIVOC}, volume = {2010}, number = {9}, pages = {31–39}, address = {AGGARWAL VK, 2005, ANGEW CHEM INT EDIT, V44, P5516, DOI}, issn = {1551-7004}, }