staff:tunde.juhasz [Biological Soft Matter Platform]

Research group	Beke-Somfai Lab: Biomolecular Self-Assembly
Role	Senior researcher
MTMT	10019488

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2026
2025
2024
2023
2022
2021
2020
2019
2018
2017
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2002

An ATP‐Mediated Antibiotic β‐Peptide Nanofiber That Kills Multidrug‐Resistant Bacteria via a Multistage Mechanism (2026)
Sohini Chakraborty, Kamal el Battioui, Dániel Molnár, Bálint Jezsó, Lejla Daruka, Tasvilla Sonallya, Tünde Juhász, Rita Hirmondó, Imola Cs. Szigyártó, Loránd Románszki, Natália Tőkési, Daniel Pinkas, Eszter Házy, Olivér Pavela, Andrea Bodor, Zoltán Varga, István Mándity, Mihály Kovács, Csaba Pál, Kata Horváti, Judit Tóth, Tamás Beke‐Somfai Advanced Science
Wiley DOI:10.1002/advs.202522269

Charge and length dependent build-up of environment sensitive lamellin β-peptides (2025)
Sohini Chakraborty, Kamal el Battioui, Tasvilla Sonallya, Imola Cs. Szigyártó, Kata Horváti, Zoltán Varga, Tünde Juhász, Tamás Beke-Somfai Physical Chemistry Chemical Physics 27/16 p8540-8551
Royal Society of Chemistry (RSC) DOI:10.1039/d4cp04561k
Residual flexibility in the topologically constrained multivalent complex between the <scp>GKAP</scp> scaffold and <scp>LC</scp> 8 hub proteins (2025)
Eszter Nagy‐Kanta, Zsófia E. Kálmán, Helena Tossavainen, Tünde Juhász, Fanni Farkas, József Hegedüs, Melinda Keresztes, Tamás Beke‐Somfai, Zoltán Gáspári, Perttu Permi, Bálint Péterfia The FEBS Journal 293/1 p76-95
Wiley DOI:10.1111/febs.70219

Mapping of the Lipid-Binding Regions of the Antifungal Protein NFAP2 by Exploiting Model Membranes (2024)
Olivér Pavela, Tünde Juhász, Liliána Tóth, András Czajlik, Gyula Batta, László Galgóczy, Tamás Beke-Somfai Journal of Chemical Information and Modeling 64/16 p6557-6569
American Chemical Society (ACS) DOI:10.1021/acs.jcim.4c00229
Functional contribution of condensate formation by single-stranded DNA binding protein (SSB) to bacterial genome maintenance (2024)
Peter Ecsédi, János Pálinkás, Zoltán Kovács, Gábor Harami, Tunde Juhasz, Balint Jezso, David Erfalvy, Lamiya Mahmudova, Eszter Házy, Tamas Beke-Somfai, Mihaly Kovacs Biophysical Journal 123/3 p79a-80a
Elsevier BV DOI:10.1016/j.bpj.2023.11.547
Categorizing interaction modes of antimicrobial peptides with extracellular vesicles: Disruption, membrane trespassing, and clearance of the protein corona (2025)
Tasvilla Sonallya, Tünde Juhász, Imola Cs. Szigyártó, Kinga Ilyés, Priyanka Singh, Delaram Khamari, Edit I. Buzás, Zoltán Varga, Tamás Beke-Somfai Journal of Colloid and Interface Science 679 p496-509
Elsevier BV DOI:10.1016/j.jcis.2024.09.244
In situ captured antibacterial action of membrane-incising peptide lamellae (2024)
Kamal el Battioui, Sohini Chakraborty, András Wacha, Dániel Molnár, Mayra Quemé-Peña, Imola Cs. Szigyártó, Csenge Lilla Szabó, Andrea Bodor, Kata Horváti, Gergő Gyulai, Szilvia Bősze, Judith Mihály, Bálint Jezsó, Loránd Románszki, Judit Tóth, Zoltán Varga, István Mándity, Tünde Juhász, Tamás Beke-Somfai Nature Communications 15/1
Springer Science and Business Media LLC DOI:10.1038/s41467-024-47708-4

Structures of calmodulin–melittin complexes show multiple binding modes lacking classical anchoring interactions (2023)
Zsolt Dürvanger, Tünde Juhász, Károly Liliom, Veronika Harmat Journal of Biological Chemistry 299/4 p104596
Elsevier BV DOI:10.1016/j.jbc.2023.104596
Probing telomeric-like G4 structures with full or partial 2′-deoxy-5-hydroxyuridine substitutions (2023)
Zoltán Szeltner, Györgyi Ferenc, Tünde Juhász, Zoltán Kupihár, Zoltán Váradi, Dávid Szüts, Lajos Kovács Biochimie 214 p33-44
Elsevier BV DOI:10.1016/j.biochi.2023.01.009
Unique thermophoretic behavior of supramolecular assemblies of cationic antimicrobial peptides with anionic small molecule agents (2023)
Tünde Juhász, Mayra Quemé-Peña, Tamás Beke-Somfai Journal of Molecular Liquids 386 p122513
Elsevier BV DOI:10.1016/j.molliq.2023.122513

A covalent strategy to target intrinsically disordered proteins: Discovery of novel tau aggregation inhibitors (2022)
László Petri, Péter Ábrányi-Balogh, Darius Vagrys, Tímea Imre, Nikolett Varró, István Mándity, Anita Rácz, Lucia Wittner, Kinga Tóth, Estilla Zsófia Tóth, Tünde Juhász, Ben Davis, György Miklós Keserű European Journal of Medicinal Chemistry 231 p114163
Elsevier BV DOI:10.1016/j.ejmech.2022.114163
Neuronal-specific septin-3 binds Atg8/LC3B, accumulates and localizes to autophagosomes during induced autophagy (2022)
Vilmos Tóth, Henrietta Vadászi, Lilla Ravasz, Dániel Mittli, Dominik Mátyás, Tamás Molnár, András Micsonai, Tamás Szaniszló, Péter Lőrincz, Réka Á. Kovács, Tünde Juhász, Tamás Beke-Somfai, Gábor Juhász, Balázs András Györffy, Katalin A. Kékesi, József Kardos Cellular and Molecular Life Sciences 79/9
Springer Science and Business Media LLC DOI:10.1007/s00018-022-04488-8
Lipid nanoparticles with erythrocyte cell-membrane proteins (2023)
Attila Bóta, Bence Fehér, András Wacha, Tünde Juhász, Dániel Szabó, Lilla Turiák, Anikó Gaál, Zoltán Varga, Heinz Amenitsch, Judith Mihály Journal of Molecular Liquids 369 p120791
Elsevier BV DOI:10.1016/j.molliq.2022.120791
Storage conditions determine the characteristics of red blood cell derived extracellular vesicles (2022)
Tímea Bebesi, Diána Kitka, Anikó Gaál, Imola Csilla Szigyártó, Róbert Deák, Tamás Beke-Somfai, Kitti Koprivanacz, Tünde Juhász, Attila Bóta, Zoltán Varga, Judith Mihály Scientific Reports 12/1
Springer Science and Business Media LLC DOI:10.1038/s41598-022-04915-7
Stimuli-Responsive Membrane Anchor Peptide Nanofoils for Tunable Membrane Association and Lipid Bilayer Fusion (2022)
Vignesh Udyavara Nagaraj, Tünde Juhász, Mayra Quemé-Peña, Imola Cs. Szigyártó, Dóra Bogdán, András Wacha, Judith Mihály, Loránd Románszki, Zoltán Varga, Joakim Andréasson, István Mándity, Tamás Beke-Somfai ACS Applied Materials & Interfaces 14/50 p55320-55331
American Chemical Society (ACS) DOI:10.1021/acsami.2c11946

Solution NMR Structure of the SH3 Domain of Human Caskin1 Validates the Lack of a Typical Peptide Binding Groove and Supports a Role in Lipid Mediator Binding (2021)
Orsolya Tőke, Kitti Koprivanacz, László Radnai, Balázs Merő, Tünde Juhász, Károly Liliom, László Buday Cells 10/1 p173
MDPI AG DOI:10.3390/cells10010173
Fluorescence-based selective nitrite ion sensing by amino-capped carbon dots (2021)
Robert Ludmerczki, Stefania Mura, Luigi Stagi, Tünde Juhász, Marco Dettori, Antonio Azara, Plinio Innocenzi, Luca Malfatti Environmental Nanotechnology, Monitoring & Management 16 p100573
Elsevier BV DOI:10.1016/j.enmm.2021.100573
New short cationic antibacterial peptides. Synthesis, biological activity and mechanism of action (2021)
Beatriz Lima, Maria Ricci, Adriana Garro, Tünde Juhász, Imola Csilla Szigyártó, Zita I. Papp, Gabriela Feresin, Jose Garcia de la Torre, Javier Lopez Cascales, Lívia Fülöp, Tamás Beke-Somfai, Ricardo D. Enriz Biochimica et Biophysica Acta (BBA) - Biomembranes 1863/10 p183665
Elsevier BV DOI:10.1016/j.bbamem.2021.183665
Interplay between membrane active host defense peptides and heme modulates their assemblies and in vitro activity (2021)
Tünde Juhász, Mayra Quemé-Peña, Bence Kővágó, Judith Mihály, Maria Ricci, Kata Horváti, Szilvia Bősze, Ferenc Zsila, Tamás Beke-Somfai Scientific Reports 11/1
Springer Science and Business Media LLC DOI:10.1038/s41598-021-97779-2
Controlling Peptide Function by Directed Assembly Formation: Mechanistic Insights Using Multiscale Modeling on an Antimicrobial Peptide–Drug–Membrane System (2021)
Gergely Kohut, Tünde Juhász, Mayra Quemé-Peña, Szilvia Erika Bősze, Tamás Beke-Somfai ACS Omega 6/24 p15756-15769
American Chemical Society (ACS) DOI:10.1021/acsomega.1c01114
Membrane Association Modes of Natural Anticancer Peptides: Mechanistic Details on Helicity, Orientation, and Surface Coverage (2021)
Mayra Quemé-Peña, Tünde Juhász, Gergely Kohut, Maria Ricci, Priyanka Singh, Imola Cs. Szigyártó, Zita I. Papp, Lívia Fülöp, Tamás Beke-Somfai International Journal of Molecular Sciences 22/16 p8613
MDPI AG DOI:10.3390/ijms22168613

Comparison of ligand binding and conformational stability of human calmodulin with its homolog from the malaria parasite Plasmodium falciparum (2020)
Tünde Juhász, József Kardos, Zsolt Dürvanger, Veronika Harmat, Károly Liliom FASEB BioAdvances 2/8 p489-505
Wiley DOI:10.1096/fba.2020-00013
Anionic food color tartrazine enhances antibacterial efficacy of histatin-derived peptide DHVAR4 by fine-tuning its membrane activity (2020)
Maria Ricci, Kata Horváti, Tünde Juhász, Imola Szigyártó, György Török, Fanni Sebák, Andrea Bodor, László Homolya, Judit Henczkó, Bernadett Pályi, Tamás Mlinkó, Judith Mihály, Bilal Nizami, Zihuayuan Yang, Fengming Lin, Xiaolin Lu, Loránd Románszki, Attila Bóta, Zoltán Varga, Szilvia Bősze, Ferenc Zsila, Tamás Beke-Somfai Quarterly Reviews of Biophysics 53
Cambridge University Press (CUP) DOI:10.1017/s0033583520000013
Membrane Active Peptides Remove Surface Adsorbed Protein Corona From Extracellular Vesicles of Red Blood Cells (2020)
Priyanka Singh, Imola Cs. Szigyártó, Maria Ricci, Ferenc Zsila, Tünde Juhász, Judith Mihály, Szilvia Bősze, Éva Bulyáki, József Kardos, Diána Kitka, Zoltán Varga, Tamás Beke-Somfai Frontiers in Chemistry 8
Frontiers Media SA DOI:10.3389/fchem.2020.00703
Old Polyanionic Drug Suramin Suppresses Detrimental Cytotoxicity of the Host Defense Peptide LL-37 (2020)
Mayra Quemé-Peña, Maria Ricci, Tünde Juhász, Kata Horváti, Szilvia Bősze, Beáta Biri-Kovács, Bálint Szeder, Ferenc Zsila, Tamás Beke-Somfai ACS Pharmacology & Translational Science 4/1 p155-167
American Chemical Society (ACS) DOI:10.1021/acsptsci.0c00155
Membrane active Janus-oligomers of β3-peptides (2020)
Imola Cs. Szigyártó, Judith Mihály, András Wacha, Dóra Bogdán, Tünde Juhász, Gergely Kohut, Gitta Schlosser, Ferenc Zsila, Vlada Urlacher, Zoltán Varga, Ferenc Fülöp, Attila Bóta, István Mándity, Tamás Beke-Somfai Chemical Science 11/26 p6868-6881
Royal Society of Chemistry (RSC) DOI:10.1039/d0sc01344g

The molecular mechanism of structural changes in the antimicrobial peptide CM15 upon complex formation with drug molecule suramin: a computational analysis (2019)
Gergely Kohut, Adam Sieradzan, Ferenc Zsila, Tünde Juhász, Szilvia Bősze, Adam Liwo, Sergey A. Samsonov, Tamás Beke-Somfai Physical Chemistry Chemical Physics 21/20 p10644-10659
Royal Society of Chemistry (RSC) DOI:10.1039/c9cp00471h
Manipulating Active Structure and Function of Cationic Antimicrobial Peptide CM15 with the Polysulfonated Drug Suramin: A Step Closer to in Vivo Complexity (2019)
Mayra Quemé‐Peña, Tünde Juhász, Judith Mihály, Imola Cs. Szigyártó, Kata Horváti, Szilvia Bősze, Judit Henczkó, Bernadett Pályi, Csaba Németh, Zoltán Varga, Ferenc Zsila, Tamás Beke‐Somfai ChemBioChem 20/12 p1578-1590
Wiley DOI:10.1002/cbic.201800801
Flow-chemistry enabled efficient synthesis of β-peptides: backbone topology vs. helix formation (2019)
Imane Nekkaa, Dóra Bogdán, Tamás Gáti, Szabolcs Béni, Tünde Juhász, Márta Palkó, Gábor Paragi, Gábor K. Tóth, Ferenc Fülöp, István M. Mándity Chemical Communications 55/21 p3061-3064
Royal Society of Chemistry (RSC) DOI:10.1039/c8cc10147g

Heparin and Heparan Sulfate Binding of the Antiparasitic Drug Imidocarb: Circular Dichroism Spectroscopy, Isothermal Titration Calorimetry, and Computational Studies (2018)
Ferenc Zsila, Tünde Juhász, Gergely Kohut, Tamás Beke-Somfai The Journal of Physical Chemistry B 122/6 p1781-1791
American Chemical Society (ACS) DOI:10.1021/acs.jpcb.7b08876
The lipid mediator lysophosphatidic acid induces folding of disordered peptides with basic amphipathic character into rare conformations (2018)
Tünde Juhász, Judith Mihály, Gergely Kohut, Csaba Németh, Károly Liliom, Tamás Beke-Somfai Scientific Reports 8/1
Springer Science and Business Media LLC DOI:10.1038/s41598-018-32786-4

Hemin and bile pigments are the secondary structure regulators of intrinsically disordered antimicrobial peptides (2017)
Ferenc Zsila, Tünde Juhász, Szilvia Bősze, Kata Horváti, Tamás Beke‐Somfai Chirality 30/2 p195-205
Wiley DOI:10.1002/chir.22784
The SH3 domain of Caskin1 binds to lysophosphatidic acid suggesting a direct role for the lipid in intracellular signaling (2017)
Kitti Koprivanacz, Orsolya Tőke, Balázs Besztercei, Tünde Juhász, László Radnai, Balázs Merő, Judith Mihály, Mária Péter, Gábor Balogh, László Vígh, László Buday, Károly Liliom Cellular Signalling 32 p66-75
Elsevier BV DOI:10.1016/j.cellsig.2017.01.019
Functional Analysis on a Naturally Occurring Variant of the Staphylococcus Aureus Uracil DNA Glycosylase Inhibitor (2017)
Veronika Papp-Kádár, Zoltán Balázs, Gergely N. Nagy, Tünde Juhász, Károly Liliom, Beáta G. Vértessy Periodica Polytechnica Chemical Engineering 62/1 p51-56
Periodica Polytechnica Budapest University of Technology and Economics DOI:10.3311/ppch.10163

Cellular and ultra structural evidence for cytoskeletal localization of prolyl endopeptidase-like protein in neurons (2013)
M. Morawski, K. Nuytens, T. Juhasz, U. Zeitschel, G. Seeger, E. Waelkens, L. Regal, I. Schulz, T. Arendt, Z. Szeltner, J. Creemers, S. Roßner Neuroscience 242 p128-139
Elsevier BV DOI:10.1016/j.neuroscience.2013.02.038

The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity (2013)
Zoltán Szeltner, Tünde Juhász, Ilona Szamosi, Dean Rea, Vilmos Fülöp, Károly Módos, Luiz Juliano, László Polgár Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1834/1 p98-111
Elsevier BV DOI:10.1016/j.bbapap.2012.08.012
Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase (2012)
Karol Kaszuba, Tomasz Róg, Reinis Danne, Peter Canning, Vilmos Fülöp, Tünde Juhász, Zoltán Szeltner, J.-F. St. Pierre, Arturo García-Horsman, Pekka T. Männistö, Mikko Karttunen, Jyrki Hokkanen, Alex Bunker Biochimie 94/6 p1398-1411
Elsevier BV DOI:10.1016/j.biochi.2012.03.012

GAP43 shows partial co-localisation but no strong physical interaction with prolyl oligopeptidase (2010)
Zoltán Szeltner, Markus Morawski, Tünde Juhász, Ilona Szamosi, Károly Liliom, Veronika Csizmók, Ferenc Tölgyesi, László Polgár Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1804/12 p2162-2176
Elsevier BV DOI:10.1016/j.bbapap.2010.09.010
Increase of SARS-CoV 3CL peptidase activity due to macromolecular crowding effects in the milieu composition (2010)
Debora N. Okamoto, Lilian C.G. Oliveira, Marcia Y. Kondo, Maria H.S. Cezari, Zoltán Szeltner, Tünde Juhász, Maria A. Juliano, László Polgár, Luiz Juliano, Iuri E. Gouvea Biological Chemistry 391/12
Walter de Gruyter GmbH DOI:10.1515/bc.2010.145

The Acylaminoacyl Peptidase from Aeropyrum pernix K1 Thought to Be an Exopeptidase Displays Endopeptidase Activity (2007)
András L. Kiss, Balázs Hornung, Krisztina Rádi, Zsolt Gengeliczki, Bálint Sztáray, Tünde Juhász, Zoltán Szeltner, Veronika Harmat, László Polgár Journal of Molecular Biology 368/2 p509-520
Elsevier BV DOI:10.1016/j.jmb.2007.02.025
Truncated prolyl oligopeptidase from Pyrococcus furiosus (2007)
Tünde Juhász, Zoltán Szeltner, László Polgár Proteins: Structure, Function, and Bioinformatics 69/3 p633-643
Wiley DOI:10.1002/prot.21522

Kosmotropic Salt Activation and Substrate Specificity of Poliovirus Protease 3C (2006)
Iuri E. Gouvea, Wagner A. S. Judice, Maria H. S. Cezari, Maria A. Juliano, Tünde Juhász, Zoltán Szeltner, László Polgár, Luiz Juliano Biochemistry 45/39 p12083-12089
American Chemical Society (ACS) DOI:10.1021/bi060793n
Properties of the prolyl oligopeptidase homologue from Pyrococcus furiosus (2006)
Tünde Juhász, Zoltán Szeltner, László Polgár FEBS Letters 580/14 p3493-3497
Wiley DOI:10.1016/j.febslet.2006.05.022

Flexibility of prolyl oligopeptidase: Molecular dynamics and molecular framework analysis of the potential substrate pathways (2005)
Monika Fuxreiter, Csaba Magyar, Tünde Juhász, Zoltán Szeltner, László Polgár, István Simon Proteins: Structure, Function, and Bioinformatics 60/3 p504-512
Wiley DOI:10.1002/prot.20508
The PREPL A protein, a new member of the prolyl oligopeptidase family, lacking catalytic activity (2005)
Z. Szeltner, I. Alshafee, T. Juhász, R. Parvari, L. Polgár Cellular and Molecular Life Sciences 62/19-20 p2376-2381
Springer Science and Business Media LLC DOI:10.1007/s00018-005-5262-5

Unclosed β-Propellers Display Stable Structures: Implications for Substrate Access to the Active Site of Prolyl Oligopeptidase (2005)
Tünde Juhász, Zoltán Szeltner, Vilmos Fülöp, László Polgár Journal of Molecular Biology 346/3 p907-917
Elsevier BV DOI:10.1016/j.jmb.2004.12.014
Concerted Structural Changes in the Peptidase and the Propeller Domains of Prolyl Oligopeptidase are Required for Substrate Binding (2004)
Zoltán Szeltner, Dean Rea, Tünde Juhász, Veronika Renner, Vilmos Fülöp, László Polgár Journal of Molecular Biology 340/3 p627-637
Elsevier BV DOI:10.1016/j.jmb.2004.05.011

Role of the Oxyanion Binding Site and Subsites S1 and S2 in the Catalysis of Oligopeptidase B, a Novel Target for Antimicrobial Chemotherapy (2002)
Tünde Juhász, Zoltán Szeltner, Veronika Renner, László Polgár Biochemistry 41/12 p4096-4106
American Chemical Society (ACS) DOI:10.1021/bi016016z
Substrate-dependent Competency of the Catalytic Triad of Prolyl Oligopeptidase (2002)
Zoltán Szeltner, Dean Rea, Tünde Juhász, Veronika Renner, Zoltán Mucsi, György Orosz, Vilmos Fülöp, László Polgár Journal of Biological Chemistry 277/47 p44597-44605
Elsevier BV DOI:10.1074/jbc.m207386200

Tünde Juhász

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